Showing posts with label Dental Updates. Show all posts
Showing posts with label Dental Updates. Show all posts

Tuesday, July 25, 2017

Worried of Teeth Abrasion by Brushing? - Please Don't. Metal Nano-particles Mouthwash can be the Remedy

          Do you suffer from tooth sensitivity or have heavy hand on brushing abrading your teeth, then your worries are nearing to the end. Russian Scientists have developed the Metal Nano-particles to kill oral bacteria.

       An innovative mouth wash developed at the National University of Science and Technology MISIS (NUST MISIS) in cooperation with researchers from Vyatka State University was shown to have a substantial impact on oral cavity micro-flora, removing about 83% of dental plaque.

      It's effectiveness was proven during clinical trials at the Dentistry Department of Kirov State Medical University.

Dentists currently recommend mouthwash and oral irrigation devices that use a stream of pulsating water to remove dental plaque; as supplement in oral hygiene which helps to kill bacteria that can cause plaque formation, and remove food debris between teeth that cannot be removed easily with a toothbrush or floss. In coordination with medical experts, NUST MISIS researchers developed an oral rinse that, if used regularly, suppresses pathogenic oral bacteria, reducing the risk of dental carries and gum diseases. The product’s effectiveness is based on the use of metal nano-particles. Experiments showed that these particles stop bacteria that cause plaque from growing.

      Svetlana Gromova, Dean of the Dentistry Department at Kirov State Medical University and the project's Co-author says, 
“Pathogenic bacteria can be killed through chemical destruction of cell walls and various membranes, including cell organelle membranes, specifically when metal nano-particles enter into contact with bio-polymers of microbial cells. The cell membrane breaks down, releasing its content into the environment. With its bactericidal and bacteriostatic properties, the solution exceeds antibiotics by far when it comes to dealing with staphylococcus aureus and most coccus varieties.”

    During clinical trials at Kirov’s Dentistry Department, volunteers were asked to use the new mouthwash for one month, and measurements were taken after 14 and 30 days of using the product. Observations shown that bacteria that cause plaque are sensitive to various solutions that contain metal oxide nano-particles. Microorganisms were also less prone to adhering to teeth and causing inflammation. If used regularly, the rinse helped to reduce the oral fungal microbes,too; normalizing salivary pH.

    Head of the research team, Associate Professor at NUST MISIS Department of Physical Chemistry, Georgy Frolov said on the scientific outcome of the experiments: 

“Colloidal solutions of metal oxides are not toxic to humans. They have a lasting anti-bacterial effect against dental plaque microorganisms, while also serving as a source of microelements. As we saw during research, using a metal oxide mouthwash substantially reduces soft dental deposits, reducing pathogenic microflora, all but eliminating it.”


     NUST MISIS laboratories are currently making the first test batches of the product, patents and registration documents for medical use have been filled.

    So, this is a big leap towards effective plaque control because the contemporary methods of plaque control fall short on one or more aspect. Even though it can't be expected from it to completely replace the tooth brushing but can be a great adjuvant to the regular mechanical method like Tooth brush and flossing. 

    Although, the mouthwash may not have the universal appeal and experts may have difference of opinion on use of mouthwash as exclusive measure of plaque control but it can be a great alternative to the people with abraded teeth and for disabled.


Friday, December 2, 2016

Humans may be able to regrow lost teeth like sharks

     

Sharks can regenerate their teeth through the network of genes, which may pave the way for the development of therapies to help humans with tooth loss, said researchers.
     
Although humans possess same cells, their tooth regeneration ability is limited. But the study has identified a network of genes that enables sharks to develop and regenerate their teeth throughout their lifetime.
    
"We know that sharks are fearsome predators and one of the main reasons they are so successful at hunting prey is because of their rows of backward pointing, razor-sharp teeth that regenerate rapidly throughout their lifetime, and so are replaced before decay," said the lead author Gareth Fraser from the University of Sheffield in Britain.
     


Researchers have identified how a special set of epithelial cells form, called the dental lamina, which are responsible for the lifelong continuation of tooth development and regeneration in sharks.
    
The genes also allow sharks to replace rows of their teeth using a conveyer belt-like system. Humans also possess this set of cells, which facilitate the production of replacement teeth, but only two sets are formed - baby and adult teeth - before this set of specialised cells is lost.
     
These "tooth" genes, therefore make all vertebrate teeth from sharks to mammals, however in mammals like humans, the tooth regeneration ability, that utilises these genes, has been highly reduced over time.
     
"The Jaws films taught us that it's not always safe to go into the water, but this study shows that perhaps we need to in order to develop therapies that might help humans with tooth loss," Fraser added.
     
Through analysing the teeth of catshark embryos, the researchers characterised the expression of genes during stages of early shark tooth formation.
     
They found that these genes participate in the initial emergence of shark's teeth and are re-deployed for further tooth regeneration.
     
The study suggests that at the beginning of the sharks' evolutionary history, their teeth were most likely continuously regenerated and used a core set of genes from members of key developmental signalling pathways, which were instrumental in sharks evolving to maintain the ability to re-deploy the genes to replace teeth when needed.

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